Integration of the Polygenic Risk Score (PRS) into the management of women at genetic or familial risk of breast cancer

Breast cancer is the most common cancer in women in Quebec and the second leading cause of cancer death. Mammography screening every two years is offered to all women between the ages of 50 and 74. Earlier or more intensive monitoring, or even preventive surgery, may be proposed for women at risk, due to their family history or a genetic hereditary predisposition. The integration of genomic data (polygenic risk score), in addition to other risk factors, should make it possible to better determine the cancer risk of these women in nearly one in two women at risk, and to offer them personalized care adapted to their actual risk of breast cancer. Women at risk would be better monitored, allowing earlier detection of their cancer, improving their prognosis and quality of life, while avoiding unnecessary screening for women at low risk. To this end, we will validate a genetic analysis of the score in the laboratory of the CHU de Québec, and integrate it into the oncogenetics clinic. Ultimately, this approach will be implemented within the framework of care in Quebec.